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pentobarbital will lower the extent or influence of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to the decrease in fentanyl plasma concentrations, deficiency of efficacy or, probably, improvement of the withdrawa